Kasturi Mitra - 51²è¹Ý

51²è¹Ý

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Kasturi Mitra

Associate Professor of Biology, 51²è¹Ý,
DBT-WellcomeTrust Senior Fellow,
Adjunct Faculty, Genetics department, University of Alabama at Birmingham

Ph.D. CCMB, Hyderabad

Kasturi Mitra joined Ashoka as a DBT- WellcomeTrust Senior Fellow. She ran a federally funded research program as an independent faculty at the University of Alabama at Birmingham, USA. There, she also directed an undergraduate program fostering student learning from hands-on experience towards forging customized learning paths. Her educational training is from Presidency College (Calcutta) for BSc, Calcutta University for MSc, CCMB (Hyderabad) for PhD and NIH (Bethesda, USA) for postdoc. Her long standing research interest is in the cellular organelles called mitochondria that are classically known as ‘the powerhouse of the cell’. Originally, mitochondria were bacteria (prokaryotes) that got integrated into the eukaryotic cells during the course of evolution, and took control of various homeostatic functions of the eukaryotic cell. Her research has been pioneering in identifying various novel aspects of mitochondrial biology in various cell types including stem cells. Her lab takes a combinatorial approach involving quantitative cell biology, biochemical and genetic tools in probing the role of mitochondria in health and in diseases like cancer. Other than research articles she has also published several invited review articles in her areas of expertise. Her research has been featured in podcasts and newsletters.

She serves as reviewer for various leading scientific journals and international funding agencies, and has served as a lead guest editor on a mitochondria-related special topic.

She encourages out of the box thinking and learning through work and play. When she is not a scientist or a teacher, she is a busy mom and a musician.

  • MayankÌýSaini,ÌýSwatiÌýAgarwala,ÌýBiratalÌýWagle,ÌýBrianÌýSpurlock,ÌýBhartiÌýGolchha,ÌýDanitraÌýParker,ÌýKasturiÌýMitra.ÌýQuantitative analyses of single mitochondrial components reveal an early role of small-mitochondrial-networks in priming neoplasticity.ÌýbioRxivÌý2024.12.26.630414;Ìýdoi:Ìý
  • Agarwala S, Dhabal S,ÌýMitra K.ÌýSignificance of quantitative analyses of the impact of heterogeneity in mitochondrial content and shape on cell differentiation.ÌýOpen Biol.Ìý2024 Jan;14(1):230279.Ìýdoi: 10.1098/rsob.230279.ÌýEpub 2024 Jan 17.ÌýReview.ÌýPubMed PMID: 38228170; PubMed Central PMCID: PMC10791538.
  • Kane MS, Benavides GA, Osuma E, Johnson MS, Collins HE, He Y, Westbrook D, Litovsky SH,ÌýMitra K, Chatham JC, Darley-Usmar V, Young ME, Zhang J.ÌýThe interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics.ÌýSci Rep.Ìý2023 Dec 7;13(1):21638.Ìýdoi: 10.1038/s41598-023-49018-z.ÌýPubMed PMID: 38062139; PubMed Central PMCID: PMC10703790.
  • Agarwala S, Saini M, Parker D andÌýMitra K*#.ÌýEnrichment of carcinogen-driven “mitochondria-primed†human skin stem cells and their identification using single-cell analyses. STAR Protocols; 4 (3), 102545; 2023.Ìý
  • Zhao Q,ÌýYan S,ÌýLu J,ÌýParker DJ, Wu H,ÌýÌýSun Q,ÌýCrossman DK,ÌýLiu S,ÌýWang Q,ÌýSesaki H,ÌýMitra K,ÌýLiu K,ÌýJiao K.ÌýMitochondrial Fission Regulates Transcription of Ribosomal Protein Genes in Embryonic Hearts.ÌýJ Cell Sci.Ìý2022 Feb 15;135(4).Ìýdoi: 10.1242/jcs.258956.ÌýEpub 2022 Feb 21.ÌýPubMed PMID: 35099001; PubMed Central PMCID: PMC8919333.
  • Spurlock B, Parker D, Basu MK, Hjelmeland A, Sajina G, Liu S, Siegal GP, Gunter A, Moran A,ÌýMitra K*.ÌýFine-tuned repression of Drp1 driven mitochondrial fission primes a ‘stem/progenitor-like state’ to accelerate neoplastic transformation.ÌýÌýeLife,ÌýSept 2021.ÌýeLife2021;10:e68394ÌýDOI:Ìý.ÌýPMID: 34545812; PMCID: PMC8497058.
  • Vu T,ÌýDatta A,ÌýBanisterÌýC, Jin L, YuanÌýG, Samuel T, Bae S,ÌýEltoumÌýI-EÌý, ManneÌýU, ZhangÌýB,ÌýÌýMitra K, Buckhaults P, Dutta P*.ÌýSTRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism.ÌýGastroenterology, 2021 Sept.ÌýGastroenterology.Ìý2021 Sep 11;S0016-5085(21)03489-2.Ìýdoi:Ìý10.1053/j.gastro.2021.09.010ÌýPMID: 34520730.
  • Spurlock, B*., Hanumanthu,ÌýV. S. andÌýMitra, K*. (2021).ÌýStrategy of Isolating ‘Primed’ Tumor Initiating Cells Based on Mitochondrial Transmembrane Potential.ÌýBio-protocolÌý11(5): e3945. DOI:Ìý.ÌýPMID: 33796619; PMCID: PMC8005873.
  • Spurlock B andÌýMitra K*#.ÌýÌýMito-SinCe2Ìýapproach to study heterogeneity in mitochondrial structure-function relationship.ÌýMethods in Molecular Biology, Springer Protocols. Mitochondrial Medicine, 2ndÌýedition, V.ÌýWeissig, M. Edeas, Editors. Humana Press, Springer New York Heidelberg Dordrecht London, 2020,Ìýin print.ÌýPubMed PMID: 34118054.
  • Spurlock B, Tullet J, Hartman JL 4th,ÌýMitra K*.ÌýExp Gerontol.Ìý2020 Jul 1;135:110919.Ìýdoi: 10.1016/j.exger.2020.110919.ÌýEpub 2020 Mar 24.ÌýReview.ÌýPubMed PMID: 32220593.
  • Spurlock B, Gupta P, Basu MK, Mukherjee A, Hjelmeland AB, Darley-Usmar V, Parker D, Foxall ME,ÌýMitra K*.ÌýNew quantitative approach reveals heterogeneity in mitochondrial structure-function relations in tumor initiating cells.ÌýJ Cell Sci. 2019 Mar 25. doi: 10.1242/jcs.230755. PMID: 30910831. (Fast tracked with encouraging review from Cell Reports).

  • Redmann M, Benavides GA, Wani WY, Berryhill TF, Ouyang X, Johnson MS, Ravi S,ÌýMitra K,ÌýBarnes S, Darley-Usmar VM, Zhang J.ÌýMethods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture.ÌýRedox Biol. 2018 Apr 10;17:59-69. doi: 10.1016/j.redox.2018.04.005. PMID: 29677567. PMCID: PMC6006680.
  • Tomer D, Chippalkatti R,ÌýMitra K,ÌýRikhy R.ÌýERK regulates mitochondrial membrane potential in fission deficient Drosophila follicle cells during differentiation.ÌýDev Biol. 2018 Feb 1;434(1):48-62. doi: 10.1016/j.ydbio.2017.11.009. PMID: 29157562.
  • Dodson M, Wani W, Redmann M, Benavides G, Johnson M, Ouyang X, Cofield S,ÌýMitra K,ÌýDarley-Usmar V, and Zhang J.ÌýRegulation of autophagy, mitochondrial dynamics and cellular bioenergetics by 4-hydroxynonenal in primary neurons.ÌýAutophagy. 2017;13(11):1828-1840. doi: 10.1080/15548627.2017.1356948. PMID: 28837411.
  • Parker D.J., Moran A andÌýMitra K*#ÌýÌýStudying mitochondrial structure and function in Drosophila ovaries.ÌýJ Vis Exp. 2017 Jan 4;(119). doi: 10.3791/54989, 2016. PMID:28117804
  • Tanwar DK, Parker DJ, Gupta P, Spurlock B, Alvarez RD, Basu MK*,ÌýMitra K*.ÌýCrosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients.ÌýOncotarget. 2016 Aug 4. doi: 10.18632/oncotarget.11047. PMID: 27509055
  • Parker D, Iyer A, Shah S, Moran A, Hjelmeland A, Basu M.K., Liu R,ÌýMitra K *.ÌýA novel mitochondrial pool of Cyclin E, regulated by Drp1, is linked to cell density dependent cell proliferation.ÌýJ Cell Sci. 2015. Nov 15; 128(22):4171-82. doi: 10.1242/jcs.172429. PMID:26446260, PMCID:PMC4712782.
  • Bernard K, Logsdon N.J., Ravi S., Xie N., Persons B.P., Rangarajan S, Zimjewski J.S.,ÌýMitra K,ÌýLiuÌýG,Ìý Darley-Usmar V.M., and Thannickal V.J.ÌýMetabolic Reprogramming is required for Myofibroblast Contractility and Differentiation.ÌýJ Biol Chem. 2015 Oct 16;290(42):25427-38. doi: 10.1074/jbc.M115.646984. PMID: 26318453. PMCID:PMC4646190.
  • Mitra K*#.ÌýMitochondrial fission-fusion at the crossroads of proliferation and differentiation.ÌýBioessays. 2013 Nov;35(11):955-64. doi: 10.1002/bies.201300011. PMID:23943303.
  • Mitchell T, Johnson MS, Ouyang X, Chacko BK,ÌýMitra K,ÌýLei X, Gai Y, Moore DR, Barnes S,Ìý Zhang J, Koizumi A, Ramanadham S and Darley-Usmar VM.ÌýDysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells.ÌýAm J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E585-99. Doi 10.1152/ajpendo.00093.2013. PMID:23820623. PMCID:PMC3761167.
  • Fu., D.,ÌýMitra K.,ÌýSengupta P., Lippincott-Schwartz J., Arias IM.ÌýCoordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization.ÌýProc Natl Acad Sci U S A. 2013 Apr 30;110(18):7288-93. doi: 10.1073/pnas.1304285110. PMID:23589864. PMCID: PMC3645550.
  • Rappole C. A.,ÌýMitra K.,ÌýWen H.,ÌýDynamic fluorescence imaging of the free radical products of X-ray absorption in live cells.ÌýOptical Nanoscopy, 2012, 1: 5.
  • Mitra K.,ÌýRikhy R., Lilly L., Lippincott-Schwartz J.ÌýDRP1 driven mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis.ÌýJ Cell Biol. 2012 May 14;197(4):487-97. doi: 10.1083/jcb.201110058. PMID:22584906. PMCID: PMC3352947. News and views. Short B. J. Cell Bio, 2012, May14; 197(4): 460. 27 Nov 2012.
  • Hailey DW, Rambold AS, Satpute-Krishnan P,ÌýMitra K,ÌýSougrat R, Kim PK, Lippincott-Schwartz J.ÌýMitochondria supply membranes for autophagosome biogenesis during starvation.ÌýCell. 2010 May 14;141(4):656-67. doi: 10.1016/j.cell.2010.04.009. PMID: 20478256. PMCID:PMC3059894. News and views. Wrighton KH. Autophagy: From one membrane to another. Nat Rev Mol Cell Biol. 2010 Jul;11(7):464. News and views. McEwan DG, Dikic I. Cell. 2010 May 14;141(4):564-6.
  • Mitra K,ÌýLippincott-Schwartz J.ÌýAnalysis of mitochondrial dynamics and functions using imaging approaches.ÌýCurr Protoc Cell Biol. 2010 Mar;Chapter 4:Unit 4.25.1-21. doi: 10.1002/0471143030.cb0425s46. PMID: 20235105. PMCID: PMC3007120
  • Mitra K. Mitochondria, in The Liver: Biology and Pathobiology, 2009, Fifth Edition (ed I. M. Arias), JohnÌýÌýÌý Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747919.ch9
  • Mitra K., Wunder Christian., Roysam B., Lin G., Lippincott-Schwartz J.ÌýA hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase.ÌýProc Natl Acad Sci U S A. 2009 Jul 21;106(29):11960-5. doi:10.1073/pnas.0904875106. PMID:19617534. PMCID: PMC2710990. Highlighted on cover. News and Views. Finkel T. and Hwang PM. 2009 Jul 21;106(29):11825-6.
  • Shivaji S., Kumar V., Mitra K., Jha KN.ÌýMammalian sperm capacitation: role of phosphotyrosine proteins.ÌýSoc Reprod Fertil Suppl. 2007;63:295-312. PMID:17566280.
  • Mitra K. and Shivaji S.ÌýProteins implicated in sperm capacitation.ÌýIndian J Exp Biol. 2005 Nov;43(11):1001-15. PMID:16313063
  • Mitra K., Rangaraj N. and Shivaji S.ÌýNovelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: correlation of its localization, tyrosine phosphorylation, and activity during sperm capacitation.ÌýJ Biol Chem. 2005 Jul 8;280(27):25743-53. PMID:15888450
  • Mitra K and Shivaji S.ÌýNovel tyrosine-phosphorylated post-pyruvate metabolic enzyme, dihydrolipoamide dehydrogenase, involved in capacitation of hamster spermatozoa.ÌýBiol Reprod. 2004 Apr;70(4):887-99. PMID:14645106

 

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